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Is SP 1 (pregnancy specific β 1 glycoprotein) elevated in cancer patients?
Author(s) -
Engvall E.,
Yonemoto R. H.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240610
Subject(s) - radioimmunoassay , cancer , glycoprotein , antibody , melanoma , medicine , pregnancy , in vivo , breast cancer , immunology , sarcoma , trophoblast , gestation , cancer research , endocrinology , biology , placenta , pathology , microbiology and biotechnology , fetus , genetics
Pregnancy‐specific β 1 ‐glycoprotein, SP 1 , was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP 1 or SP 1 ‐like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera from patients with infectious diseases, and in none out of 15 sera from non‐pregnant healthy individuals. SP 1 thus does not seem to be ectopically produced in vivo by the types of cancer studied, but is probably highly specific for the normal and malignant trophoblast.