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14q translocations, having a break point at 14q13, in lymphoid malignancy
Author(s) -
Fukuhara Shirou,
Ueshima Yoshimi,
Shirakawa Shigeru,
Uchino Haruto,
Morikawa Shigeru
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240606
Subject(s) - chromosomal translocation , malignancy , chromosome , pathology , pleural effusion , biology , chromosomal rearrangement , medicine , cancer research , karyotype , genetics , gene
In three patients with non‐Hodgkin lymphomas and in one cell line (HPL‐Hod) derived from pleural effusion cells of a patient with Hodgkin's disease, rearrangements of the long arm of chromosome No. 14(14q) were observed. These rearrangements appeared to be consistently associated with a 14q translocation, suggestive of occurrence of a break at 14q13. The translocation in an individual case could occur with 1p, 2q, 4q, and another 14q. A 14q13 translocation may be comparable with a 14q32 translocation, which has often been observed in various types of lymphoid malignancy.