Premium
Glycophorin a as a cell surface marker of early erythroid differentiation in acute leukemia
Author(s) -
Andersson Leif C.,
Gahmberg Carl G.,
Teerenhovi Lasse,
Vuopio Pekka
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240603
Subject(s) - glycophorin , sialoglycoprotein , antiserum , leukemia , biology , immunofluorescence , acute leukemia , precursor cell , cell , immunology , immune system , microbiology and biotechnology , cancer research , antigen , antibody , biochemistry
We show here that the leukemic blast cells from three patients of a total of 15 subsequently diagnosed as having acute leukemia express on their surface the major red cell sialoglycoprotein, glycophorin A (GP‐A). This was demonstrated (1) by indirect immunofluorescence using rabbit anti GP‐A antiserum and (2) by immune precipitation of GP‐A from surface radiolabelled leukemic cells. Since GP‐A is exclusively present on erythroid cells and their precursors, these findings indicate that a higher proportion of the blast leukemias than previously recognized show features of early erythroid differentiation.