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Sister chromatid exchange in PH 1 ‐positive chronic myelocytic leukemia
Author(s) -
Becher Reinhard,
Schmidt Carl G.,
Theis Gabriele,
Hossfeld Dieter K.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240602
Subject(s) - sister chromatid exchange , myelocytic leukemia , bone marrow , sister chromatids , leukemia , medicine , microbiology and biotechnology , genetics , biology , dna , chromosome , gene
The sister chromatid exchange (SCE) frequency in bone‐marrow cells of 12 untreated patients with chronic myelocytic leukemia (CML) was analysed and compared with the SCE frequency in bone‐marrow cells of nine healthy persons. In normal persons the SCE ranged from 3.64 to 5.15 per cell. In CML patients the SCE was significantly lower, ranging from 2.32 to 3.44 per cell. The differences found were unrelated to patients' age and contraction state of the chromosomes. It is suggested that the leukemic process could account for the low SCE rate.