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Anti‐tumor potential of retinoic acid: Stimulation of immune mediated effectors
Author(s) -
Patek Paul Q.,
Collins John Leslie,
Yogeeswaran Ganesa,
Dennert Gunther
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240516
Subject(s) - retinoic acid , in vivo , retinoid , stimulation , immune system , effector , tretinoin , biology , cancer research , growth inhibition , immunology , in vitro , endocrinology , cell culture , biochemistry , genetics , microbiology and biotechnology
Data are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A × TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymus‐dependent immune‐mediated effectors able to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition.