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Lung tumors from PuO 2 ‐ZrO 2 aerosol particles in syrian hamsters
Author(s) -
Thomas R. G.,
Smith D. M.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240512
Subject(s) - inhalation , lung , syrian hamsters , respiratory tract , microsphere , aerosol , medicine , nuclear medicine , pathology , carcinogenesis , respiratory system , chemistry , hamster , anesthesia , cancer , organic chemistry , chemical engineering , engineering
Syrian golden hamsters were given PuO 2 /ZrO 2 particles via inhalation and/or Pu‐laden ZrO 2 ceramic 10‐μm diameter microspheres lodged in the capillary bed of the lung. The mean initial lung burdens ranged from 8 nCi to 143 nCi for the six experimental groups of animals. Significant numbers of primary lung tumors (5–50% per group) were induced in those animals that received inhalation exposures. Additional alpha radiation administered via Pu‐laden intravenous microspheres had little or no effect on tumorigenesis or the production of non‐neoplastic, degenerative changes in the respiratory tract.