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Antibody‐dependent cell‐mediated cytotoxicity against epstein‐barr virus membrane antigen in african Burkitt's lymphoma
Author(s) -
Granlund David J.,
Nkrumah Francis,
Perkins I. Virginia,
Biggar Robert J.,
Levine Paul H.,
Fuccillo David A.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240508
Subject(s) - antibody dependent cell mediated cytotoxicity , immunology , titer , lymphoma , antigen , antibody , virus , virology , medicine , cytotoxicity , antibody titer , burkitt's lymphoma , epstein–barr virus , biology , monoclonal antibody , in vitro , biochemistry
Serial samples of sera from patients with African Burkitt's lymphoma were tested for antibody against Epstein‐Barr virus (EBV)‐specific membrane antigen (MA) by the antibody‐dependent cell‐mediated cytotoxicity assay (ADCC). Titers of patients in the long‐term survivor group were generally higher than those found in the sera of patients in the short‐term survivor group. Although ADCC titers to EBV‐MA were not useful in predicting which patients would relapse there was a definite relationship between ADCC titer and prognosis. The individual differences in ADCC titers in patients in remission may explain the variability of responses that have been reported in studies on serotherapy with remission plasma.