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Epstein‐barr virus specific IgA serum antibodies in nasopharyngeal and other respiratory carcinomas
Author(s) -
Desgranges C.,
DeThé G.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240506
Subject(s) - nasopharyngeal carcinoma , antibody , virus , immunoglobulin a , epstein–barr virus , carcinoma , medicine , respiratory system , immunology , pathology , immunoglobulin g , radiation therapy
In order to better understand the relationship between IgA and IgG antibodies to Epstein‐Barr virus (EBV) in nasopharyngeal carcinoma (NPC), we analyzed 230 NPC sera but also a series of sera from patients with other carcinomas selected for their high EBV/IgG antibody titres. We were surprised to find that 21 out of 46 sera from bronchopulmonary carcinomas (BPC) and 6 out of 7 carcinomas of nasal fossae were IgA anti‐VCA positive, and 9 BPC sera and 5 nasal fossae sera were also positive for IgA anti‐EA. Bronchial undifferentiated small‐cell carcinomas may represent a particular group associated with high EBV profile.