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Effect of anti‐mouse type‐1 interferon globulin on the evolution of moloney sarcoma virus induced disease in mice
Author(s) -
Inglot Anna D.,
Inglot Olga,
Zóltowska Albina,
Oleszak Emilia
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240411
Subject(s) - interferon , neoplasm , virus , sarcoma , immunology , biology , ratón , disease , antigen , medicine , virology , pathology , genetics
The prolonged administration of potent sheep anti‐mouse type‐1 interferon globulin (anti‐IF IgG) had a marked potentiating effect on Moloney sarcoma virus (MSV) infection in mice. The extent of resistance to the MSV‐induced disease was age‐related. In 4‐week‐old BALB/c mice, anti‐IF IgG consistently induced 70–80% mortality due to the progression of early or late tumours and erythro‐leukaemia, whereas mortality of control mice was significantly lower. The same effect was obtained in 1‐year‐old BALB/c mice. However, in 4‐week‐old C57BL/6 or 6‐week‐old BALB/c mice, anti‐IF IgG enhanced only the growth of early tumours but had no effect on their regression. Antigenic stimulation with normal sheep globulin suppressed the growth of early tumours in suckling BALB/c or C57BL/6 mice and enhanced the evolution of late MSV‐induced disease in older mice.