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Occurrence of heat‐labile regan type of alkaline phosphatase in hematopoietic tumors
Author(s) -
Damle S. R.,
Shetty P. A.,
Jussawalla D. J.,
Bhide S. V.,
Baxi A. J.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240404
Subject(s) - alkaline phosphatase , isozyme , placental alkaline phosphatase , haematopoiesis , lymphoma , phosphatase , biochemistry , chemistry , enzyme , biology , immunology , microbiology and biotechnology , stem cell
The physicochemical and immunological properties of alkaline phosphatase extracted from Hodgkin's nodes, non‐Hodgkin's lymphoma nodes and leukemic leukocytes have been studied. The alkaline phosphatase from these three tumor types possesses the same biophysical and biochemical properties and immunological determinants as the placental alkaline phosphatase. However, it is more heat‐labile than the placental isoenzyme. Immunological experiments indicate that, of these tumor types, Hodgkin's tumor contains the largest amounts of heat‐labile Regan type of alkaline phosphatase.