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Demonstration of chicken fetal antigen (CFA) on normal splenic lymphocytes, Marek's disease lymphoblastoid cell lines and other neoplasms
Author(s) -
Murthy K. K.,
Dietert R. R.,
Calnek B. W.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240313
Subject(s) - marek's disease , lymphoblast , antigen , virus , biology , fetus , virology , cell culture , immunology , pathology , medicine , pregnancy , genetics
Chicken fetal antigen (CFA) was detected on normal splenic lymphocytes and a direct relationship was observed between the percentage of CFA‐positive cells and the age of the donor. The fetal antigen was also detected on lymphoblastoid tumor cells and cell lines induced by known avian oncogenic viruses (Marek's disease virus and avian leukosis virus), and on spontaneously occurring adenocarcinoma cells. The fetal antigen appears to be distinct from Marek's disease tumor‐associated surface antigen.