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Chromosome breaking activity of human feces and its enhancement by transition metals
Author(s) -
Stich Hans F.,
Kuhnlein Urs
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240303
Subject(s) - feces , chinese hamster ovary cell , chromosome , human feces , catalase , biology , methanol , transition (genetics) , microbiology and biotechnology , hamster , chemistry , chloroform , cell culture , genetics , biochemistry , enzyme , chromatography , gene , organic chemistry
Chloroform‐methanol extracts from human fecal samples were found to contain compounds which induce chromosome aberrations in Chinese hamster ovary cells. The induction of chromosome aberrations is stimulated by Cu 2+ or Mn 2+ and inhibited by Fe 2+ or Fe 3+ . Addition of catalase to the fecal extract or the mixture of fecal extract and Mn 2+ reduced the frequency of chromosome aberrations. These properties are indicative of hydroxyradical producing agents.