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Cell lines with spontaneous secretion of pregnancy‐associated α 2 ‐globulin
Author(s) -
Lundgren E.,
Damber M. G.,
Roos G.,
von Schoultz B.,
Stigbrand T.,
Nilsson K.,
Alexander J. J.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240108
Subject(s) - secretion , cell culture , radioimmunoassay , lymphoma , biology , cell , endocrinology , medicine , immunology , microbiology and biotechnology , biochemistry , genetics
Pregnancy‐associated α 2 ‐globulin (PA α 2 G) was quantitated by radioimmunoassay in culture media from 34 exponentially growing human cell lines. Only 8/34 cell lines produced PA α 2 G. The highest secretion was found in cell lines of histiocytic lymphoma origin while it was low in some carcinoma‐derived lines. The results may support an assumption that PAα 2 G is a normal cell product of B‐lymphoid, monocytic and epithelial cells but may also simply indicate that ectopic PAα 2 G production is especially common in tumors derived from such cells. The availability of PAα 2 G‐producing cell lines should facilitate studies of the immunoregulatory role of this protein.