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HLA antigens in familial Hodgkin's disease
Author(s) -
Greene Mark H.,
McKeen Elisabeth A.,
Li Frederick P.,
Blattner William A.,
Fraumeni Joseph F.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230607
Subject(s) - proband , human leukocyte antigen , disease , immunology , antigen , medicine , biology , genetics , pathology , mutation , gene
In a study of 13 families prone to Hodgkin's disease, the probands showed significant excesses of the HLA antigens Bw35 (7 cases) and Bw37 (3 cases). Although based on a small number of patients, the results suggest that immunogenetic mechanisms account at least partly for the familial predisposition to Hodgkin's disease.