Premium
Non‐random duplication of chromosome 15 in murine T‐cell leukemias induced in mice heterozygous for translocation 1(14:15)6
Author(s) -
Wiener Francis,
Spira Jack,
Ohno Shinsuke,
HaranGhera Nechama,
Klein George
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230410
Subject(s) - chromosomal translocation , biology , gene duplication , trisomy , chromosome , genetics , chromosome 21 , dmba , microbiology and biotechnology , gene , aneuploidy , carcinogenesis
Trisomy of chromosome 15 is a highly regular feature of murine T‐cell leukemogenesis. We have studied the chromosomal constitution of 7,12‐dimethylbenz( a )anthracene (DMBA)‐induced T‐cell leukemias in C57BL × CBAT6T6 F, mice. The CBAT6T6‐derived chromosome 1(14:15)6 was regularly duplicated whereas the C57BL‐derived normal chromosome 15 was only present in one copy. It was concluded that the gene(s) that tend to duplicate in parallel with the neoplastic transformation of the prothymocyte to an overt leukemie cell have a greater chance of duplicating and/or may have a stronger promoting effect on leukemogenesis if located on the CBA‐derived, structurally rearranged T(14:15)6 than the corresponding genes located on the C57BL‐derived normal chromosome 15.