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Discrepant effects of interferon on murine syngeneic ascites tumors and their solid metastastzing counterparts
Author(s) -
Ryd W.,
Hagmar B.,
Lundgren E.,
Strannegård Ö.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230319
Subject(s) - ascites , solid tumor , interferon , animal model , interferon alfa , cancer research , alpha interferon , medicine , immunology , cancer
The effects of interferon on mice with syngeneic tumors growing either intraperitoneally or as solid tumors were analyzed. The same dose that depressed the growth of ascites tumors, enhanced growth and in one case metastasizability of the corresponding solid tumors. The possibility that this was due to some host reaction is discussed. It seems important to develop animal models for analyzing interferon effects before treatment is initiated in human tumor disease.