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Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny
Author(s) -
Paigen Beverly,
Ward Elizabeth,
Steenland Kyle,
Havens Mary,
Sartori Pamela
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230307
Subject(s) - bladder cancer , cancer , enzyme , medicine , distribution (mathematics) , biology , carcinogen , endocrinology , biochemistry , mathematical analysis , mathematics
Abstract We investigated the possible influence of aryl hydrocarbon hydroxylase (AHH) on susceptibility to bladder cancer in humans. AHH inducibility was measured in the cultured lymphocytes of 16 patients who were being followed after successful treatment for bladder cancer, in 53 progeny of bladder cancer patients, and in matched controls. In both the progeny and patient populations, no evidence was found for a difference between the distribution of AHH inducibility or induced AHH activity compared to the distribution among control individuals. Thus, AHH activity or inducibility does not appear to be a major determinant of bladder cancer risk in humans.