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Cell surface glycoprotein analysis: A diagnostic tool in human leukemias
Author(s) -
Andersson Leif C.,
Gahmberg Carl G.,
Shmes Martti A.,
Teerenhovi Lasse,
Vuopio Pekka
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230306
Subject(s) - glycoprotein , cell , biology , medicine , cancer research , immunology , pathology , computational biology , microbiology and biotechnology , genetics
We have radiolabelled surface glycoproteins of different types of leukemic cell. The labelled proteins were separated by polyacrylamide slab gel electrophoresis and visualized by fluorography. Surface glycoprotein patterns discriminatory for acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL). acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) were found. We conclude that the analysis of the surface glycoprotein profile provides a useful method for the classification of leukemic cells according to cell type and stage of differentiation.