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Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma
Author(s) -
Gahmberg Carl G.,
Sekki Akseli,
Kosunen Timo U.,
Holsti Lars R.,
Mäkelä Olavi
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230305
Subject(s) - lung cancer , hydrocarbon , malignancy , carcinoma , population , aryl , aromatic hydrocarbon , medicine , chemistry , endocrinology , organic chemistry , alkyl , environmental health
Aryl hydrocarbon hydroxylase activity in lymphoblasts from normal Finnish adults and from patients with pulmonary carcinomas and other types of malignancy has been studied by a modification of previously used techniques. High absolute induced aryl hydrocarbon hydroxylase activity was found in 39% of patients with untreated lung cancer but only in 15% of normal people. No increased frequency was found in the control group comprising other malignancies. The diagnosis of pulmonary carcinoma was made at a lower mean age (4.9 years younger) in the individuals with high aryl hydrocarbon hydroxylase activity than in those with low activity. High absolute aryl hydrocarbon hydroxylase activity was dominantly inherited in normal individuals, and the frequency of the Ah b gene in the Finnish population was 8%.