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Homogeneously staining regions on marker chromosomes in malignancy
Author(s) -
Kovacs Gy.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230304
Subject(s) - staining , malignancy , pathology , biology , chromosome , marker chromosome , positive staining , cytogenetics , karyotype , medicine , genetics , gene
Direct chromosome analysis with G‐banding revealed homogeneously staining regions (HSR) in five of 16 human solid malignant tumours of different histological types. The HSRs were localized either terminally or interstitially on the marker chromosomes. The great stability of the HSR‐carrying markers in the tumour cells suggests an interrelationship of malignant cell proliferation with the HSR. In a single case the HSR showed a moderate staining intensity for C‐heterochromatin.