Premium
Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination
Author(s) -
Murthy A. S. Krishna,
Baker John R.,
Smith Emil R.,
Zepp Ellen
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230217
Subject(s) - sodium nitrite , nitrite , carcinogen , in vivo , endocrinology , sodium , medicine , chemistry , ratón , biology , biochemistry , food science , nitrate , microbiology and biotechnology , organic chemistry
In projected 485‐day studies, Fischer 344 rats and C57BL/6 mice were fed 0.58% butylurea and 0.50% sodium nitrite mixed in the diet separately or in combination. The number and type of neoplasms were not significantly increased in either species receiving butylurea or sodium nitrite only. Feeding the two chemicals simultaneously induced neoplasms of the lung, Zymbal's gland, forestomach, intestine and hemopoietic tissues in rats, and malignant lymphomas in mice. The increased incidence of neoplasms in rats and mice fed butylurea and sodium nitrite in combination may result from in vivo formation of the carcinogen, N‐butyl‐N‐nitrosourea.