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The effects of hyalurodinase upon tumor formation in BALB/c mice painted with 7,12‐dimethylbenz‐( a )anthracene
Author(s) -
Pawlowski Andrew,
Haberman Herbert F.,
Me I. Aravindakshan
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230118
Subject(s) - dmba , 7,12 dimethylbenz[a]anthracene , hyaluronidase , chemistry , carcinogen , anthracene , saline , carcinogenesis , endocrinology , medicine , biochemistry , enzyme , organic chemistry , gene
Experiments were performed to investigate the effects of hyaluronidase on chemical carcinogenesis. Two experiments were carried out using BALB/c mice. In the first experiment the mice were divided into three groups, viz. (1) painted with 7, 12‐dimethyl‐benz( a )anthracene (DMBA), (2) injected with hyaluronidase and painted with DMBA and (3) injected with saline and painted with DMBA. In the second experiment the mice were divided into three groups: (1) painted with DMBA, (2) injected with hyaluronidase and painted with DMBA and (3) injected with heat‐inactivated hyaluronidase and painted with DMBA. The tumor incidence and size of tumors were significantly lower in the group treated with hyaluronidase than in the other groups. The latent period was increased. The mitotic index of the skin adjacent to the tumors at the end of the experiment was decreased. These studies show that hyaluronidase can act as an anticarcinogenic agent.

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