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Carcinogenic potential of hycanthone in mice and hamsters
Author(s) -
Bulay Orhan,
Urman Huseyin,
Patil Kashinath,
Clayson David B.,
Shubik Philippe
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230117
Subject(s) - intramuscular injection , carcinogen , physiology , medicine , incidence (geometry) , intraperitoneal injection , biology , biochemistry , physics , optics
Hycanthone was administered to Schistosomo monsoni‐infected and non‐infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepatomas and hepatocellular carcinomas increased from 3.4% in untreated mice to 10.6% in those treated with hycanthone. Non‐infected control mice developed 0.8% of these tumors compared to 10.2% in mice treated with hycanthone. Despite the use of high dose levels of hycanthone, statistical significance was attained only with non‐infected female mice injected intraperitoneally and intramuscularly with hycanthone and then only at confidence levels of 92 and 95% respectively.