14q+ marker chromosome in an EBV‐genome‐negative lymph node without signs of malignancy in a patient with EBV‐genome‐positive nasopharyngeal carcinoma | Zendy

Mitelman F. | Zendy; Klein G. | Zendy; AnderssonAnvret M. | Zendy; Forsby N. | Zendy; Johansson B. | Zendy

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14q+ marker chromosome in an EBV‐genome‐negative lymph node without signs of malignancy in a patient with EBV‐genome‐positive nasopharyngeal carcinoma

Author(s) -

Mitelman F.,

Klein G.,

AnderssonAnvret M.,

Forsby N.,

Johansson B.

Publication year - 1979

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910230107

Subject(s) - nasopharyngeal carcinoma , malignancy , lymphoma , pathology , biology , chromosome , lymph node , carcinoma , genome , chromosomal translocation , cancer research , medicine , gene , genetics , radiation therapy

In a patient with an EBV‐genome‐positive naso‐pharyngeal carcinoma, an EBV‐genome‐negative inguinal lymph node without histological evidence of malignant lymphoma or metastatic carcinoma growth was found to contain a 14q+ marker chromosome, identified as an 8;14 translocation, in all cells analyzed. This observation Indicates that chromosome aberrations may precede histological signs of malignancy. The possible implication of this finding in relation to the postulated role of the 14q + marker and lymphoma development is discussed.

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