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14q+ marker chromosome in an EBV‐genome‐negative lymph node without signs of malignancy in a patient with EBV‐genome‐positive nasopharyngeal carcinoma
Author(s) -
Mitelman F.,
Klein G.,
AnderssonAnvret M.,
Forsby N.,
Johansson B.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230107
Subject(s) - nasopharyngeal carcinoma , malignancy , lymphoma , pathology , biology , chromosome , lymph node , carcinoma , genome , chromosomal translocation , cancer research , medicine , gene , genetics , radiation therapy
In a patient with an EBV‐genome‐positive naso‐pharyngeal carcinoma, an EBV‐genome‐negative inguinal lymph node without histological evidence of malignant lymphoma or metastatic carcinoma growth was found to contain a 14q+ marker chromosome, identified as an 8;14 translocation, in all cells analyzed. This observation Indicates that chromosome aberrations may precede histological signs of malignancy. The possible implication of this finding in relation to the postulated role of the 14q + marker and lymphoma development is discussed.