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Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families
Author(s) -
Cheng WindShow,
Mulvihill John J.,
Greene Mark H.,
Pickle Linda W.,
Tsai Shien,
WhangPeng Jacqueline
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910230103
Subject(s) - chronic myelogenous leukemia , leukemia , sister chromatid exchange , cancer , medicine , sister chromatids , philadelphia chromosome , immunology , oncology , cancer research , biology , chromosomal translocation , chromosome , genetics , gene , in vitro
Spontaneouas sister chromatid exchanges and banded karyotypes were studied in blood lymphocytes from 96 individuals: seven patients with chronic myelogenous leukemia, 15 normal controls, and five “cancer families” comprising 12 cancer patients, 40 tumor‐free blood relatives and 22 spouses. The families had: malignant melanoma; Epstein‐Barr virus‐associated malignancies and a birth defect syndrome; non‐Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t‐test) in tumor patients and their blood relatives in cancer‐prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. In patients at high risk of cancer (because they have chronic myelogenous leukemia or a strong family history of cancer), spontaneous sister chromatid exchange rates were not a marker of cancer risk.