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Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity
Author(s) -
Mantovani Alberto
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220617
Subject(s) - immunogenicity , in vitro , sarcoma , cancer research , biology , immunology , virology , medicine , immune system , pathology , biochemistry
Macrophages were isolated from the strongly immunogenic, non‐metastasizing FS6 sarcoma transplanted in syngeneic C57BL/6 mice and from a weakly immunogenic, spontaneously metastasizing line (mFS6) of the same tumor. Macrophages isolated from the FS6 sarcoma non‐specifically inhibited growth and DNA synthesis of tumor cells in vitro . After culture FS6 macrophages rapidly lost their cytotoxic activity and became capable of non‐specifically stimulating tumor growth in vitro . Macrophages obtained from the mFS6 tumor non‐specifically enhanced the proliferative activity of tumor target cells and this capacity was maintained when the macrophages were cultured.