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The effect of fibre size on the in vitro biological activity of three types of amphibole asbestos
Author(s) -
Brown R. C.,
Chamberlain M.,
Griffiths D. M.,
Timbrell V.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220614
Subject(s) - asbestos , amphibole , materials science , composite material , chemistry , quartz
Three standard (UICC) samples of amphibole asbestos were subjected to ball‐milling; the main effect of this procedure was to reduce the length of the fibres present in each sample. The numbers of fibres in unit masses, and the distribution of fibre sizes in all the samples, both parent and milled, were estimated from electron micrographs. The ability of all the samples to reduce the plating efficiency of V79‐4 cells is compared, on the basis of mass, fibre number and fibre number above various length thresholds. This biological activity of all the samples correlated best with the number of fibres above a threshold length of 6.5 μm. This is compared with the sizes of fibre previously reported to induce mesotheliomata when implanted into the pleural cavities of rats.