Premium
Stimulation of human NK‐cell activity by cultured cells. I. Response of normals
Author(s) -
Grohmann P.,
Holmes W.,
Porzsolt F.,
Quirt I.,
Miller R. G.,
Phillips R. A.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220504
Subject(s) - stimulation , cytotoxicity , melanoma , peripheral blood , cell culture , cell , immunology , tumor cells , biology , cancer research , in vitro , endocrinology , biochemistry , genetics
Natural cell‐mediated cytotoxicity, observed on co‐cultivation of peripheral blood lymphocytes (PBL) with malignant melanoma tumor cells (M 4 ), is described. The activity was inhibited when PBL were cultured in autologous serum. Studies using competitive inhibition with cold targets and stimulation of PBL with other tumor cell lines failed to detect specificity.