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Longitudinal studies of chromosomal abnomalities and reticulum cell proliferation in new zealand black mice
Author(s) -
Friedman J. M.,
Fialkow Philip J.,
East June,
Bryant Jean I.,
Salo Armi C.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220414
Subject(s) - biology , aneuploidy , pathology , spleen , neoplastic cell , reticulum cell sarcoma , endoplasmic reticulum , cell , neoplasm , immunology , chromosome , genetics , medicine , gene
A longitudinal study of 40 New Zealand Black (NZB) mice and 20 BALB/c control animals was performed. A significant association was observed between the presence of acquired spleen‐cell aneuploidy at some time during life and development of histological evidence of reticulum‐cell neoplasia in individual animals. This finding is compatible with the hypothesis that aneuploid clones which arise in the spleens of aging NZBs are at least potentially neoplastic. However, no relationship between histologically neoplastic reticulum cell proliferation and aneuploidy was apparent in single splenic specimens obtained from NZB mice of various ages. This lack of association indicates that failure to detect chromosomal abnormalities on direct study of cells from a tumor cannot be taken as evidence that the neoplastic cells themselves lack such abnormalities.