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Delayed hypersensitivity reactions of cancer patients to antigens on lymphoid cell lines
Author(s) -
Levine P. H.,
Ho J. H. C.,
Nkrumah F.,
Periman P.,
Mourali N.,
Can G.,
Middleton M. B.,
Perkins I. V.,
Herberman R.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220406
Subject(s) - lymphoma , antigen , nasopharyngeal carcinoma , cell culture , medicine , in vivo , immunology , cancer , cancer research , pathology , biology , radiation therapy , genetics , microbiology and biotechnology
Four‐hundred and fifty niné cancer patients were skin tested with extracts from five lymphoid cell lines. More than 50% of patients with lymphoma had positive skin tests with the extracts prepared from the cell line derived from Burkitt's lymphoma (BL) and more than 50% of nasopharyngeal carcinoma (NPC) patients reacted to the NPC‐derived cell line extracts. Although the significant association between patient diagnosis and origin of cell lines suggested that tumor‐associated antigens were responsible for the pattern of delayed hyper‐sensitivity, problems in standardization of antigen potency and non‐specificity need to be resolved before this in vivo assay achieves its full potential.