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Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast
Author(s) -
Balkwill F.,
Watling D.,
TaylorPapadimitriou J.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220307
Subject(s) - lymphoblast , interferon , in vitro , cell growth , human breast , inhibitory postsynaptic potential , biology , cell cycle , cell , cell culture , chemistry , microbiology and biotechnology , cancer research , endocrinology , immunology , biochemistry , cancer cell , cancer , genetics
Abstract Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10 3 international units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth potential of cells at lower density in colony‐forming cultures was not completely recovered. Studies on the cell cycle distribution of interferon‐treated cells demonstrated that the growth‐inhibitory effect was not due to an effect on one specific phase of the cell cycle, but to a lengthening of all phases.