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Antibody‐dependent cellular cytotoxicity against epstein‐barr virus‐associated antigens in african patients with nasopharyngeal carcinoma
Author(s) -
Pearson Gary R.,
Johansson Bo,
Klein George
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220203
Subject(s) - antibody dependent cell mediated cytotoxicity , nasopharyngeal carcinoma , titer , antibody titer , immunology , antibody , medicine , cytotoxicity , antigen , biology , radiation therapy , monoclonal antibody , biochemistry , in vitro
Antibody‐dependent cellular cytotoxicity (ADCC) was performed on serum samples from African patients with nasopharyngeal carcinoma (NPC) to determine whether antibody titers determined by this assay might be of prognostic value in this disease. The serum donors were divided into two groups: (1) those individuals who died within 2 years following diagnosis of NPC; and (2) individuals who responded well to therapy and survived for more than 2 years following diagnosis. The ADCC GMT for the survivor group was significantly higher than the GMT for non‐survivors (5,410 versus 615). Interestingly, there were a number of discordant sera in the non‐survivor group that had very low ADCC titers (<240) at diagnosis in the presence of high VCA titers. When ADCC titers were compared with anti‐EA or IgA antibody titers to VCA, a statistically significant inverse correlation was noted. These data suggest that ADCC titers might be of prognostic importance in African NPC.