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Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity
Author(s) -
Mourali Nejib,
Levine Paul H.,
Tabanne Francoise,
Belhassen Slim,
Bahi Jacqueline,
Bennaceur Meri,
Herberman Ronald B.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910220102
Subject(s) - breast cancer , delayed hypersensitivity , medicine , pathology , cancer , immunology , immune system
Abstract Delayed hypersensitivity reactions to a battery of antigens were measured in 145 Tunisian breast cancer patients to determine whether an immuno‐logic mechanism could be detected which might explain the high frequency (60%) of the rapidly progressing form in Tunisian breast cancer patients. Although a greater proportion (30%) of patients with rapidly progressing breast cancer reacted to extracts of a breast tumor antigen (2937) than patients without PEV (9%), no significant difference between PEV and non‐PEV patients could be found in reactivity to DNCB, standard microbial antigens, or extracts from tissue culture cell lines. Rapidly progressing breast cancer in Tunisia is not associated with an impairment of delayed hypersensitivity.