Premium
Effects of corynebacterium parvum and cortisone on the primary lewis tumour and its metastases
Author(s) -
Jones P. D. E.,
Sadler T. E.,
Castro J. E.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210617
Subject(s) - corynebacterium parvum , cortisone , medicine , lung , lewis lung carcinoma , carcinoma , metastasis , immunology , cancer
The effects of Corynebacterinm parvum and cortisone acetate (CA) on the primary Lewis lung carcinoma and its pulmonary metastases were investigated. C. parvum given IV either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg CA (high‐dose) given SC 4 and 11 days after tumour, alone or in combination with C. parvum , administered on day 0, reduced primary tumour growth to the same extent as C. parvum alone. High‐dose CA given on days 2 and 6 had no effect on primary tumour growth or the action of C. parvum , administered on day 7, while 0.05 mg CA (low‐dose) given on days 4 and 11 did not alter tumour growth or the action of C. parvum , given at the same time as tumour. High‐dose CA given 4 and 11 days after tumour caused a significant enhancement in metastases. C. parvum given to these mice on the same day as tumour significantly reduced the pulmonary nodules but only to the level found in control, saline‐treated mice. In mice given C. parvum alone, metastases were significantly reduced when compared with controls. Similarly, high‐dose CA given on days 2 and 6 significantly enhanced metastases, and C. parvum on day 7 reduced their level to that found in control mice. Low‐dose CA had no effect on the number of metastases or the antimetastatic action of C. parvum. The relevance of these results to the clinical situation is discussed.