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Heterogeneity among human lymphocyte effector cells mediating spontaneous lymphocyte‐mediated cytotoxicity
Author(s) -
Vessella Robert L.,
Lange Paul H.,
Gormus B. J.,
Kaplan Manuel E.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210509
Subject(s) - antibody dependent cell mediated cytotoxicity , lymphocyte , cytotoxicity , effector , immunology , biology , population , t lymphocyte , receptor , antibody , flow cytometry , microbiology and biotechnology , immune system , in vitro , medicine , biochemistry , monoclonal antibody , environmental health
The spontaneous lymphocyte‐mediated cytotoxicity(SLMC) of lymphocytes from normal individuals was studied using the lymphocyte titration assay. Various techniques were used to study selectively several lymphocyte subpopulations. The activity of these subpopulations was tested in both the antibody‐dependent cellular cytotoxicity (ADCC) and lymphocyte titration assays. Surface marker studies were performed on each lymphocyte subpopulation. The results from these studies indicate that effector cells mediating SLMC are a heterogeneous lymphocyte population composed of Fc‐receptor‐positive lymphocytes both with and without C3 receptors that consistently segregate with cells that do not form rosettes with sheep red blood cells. Our data suggest that, in many respects, the effector cells in SLMC and ADCC are identical. However, the mechanism appears to be different.