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Accelerated growth of syngeneic tumors in mice treated with methylcholanthrene
Author(s) -
Lill Patsy H.,
Jessup J. Milburn,
Kripke Margaret L.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210418
Subject(s) - methylcholanthrene , immune system , in vivo , immunology , delayed hypersensitivity , antigen , neoplasm , ratón , cancer research , medicine , biology , carcinogen , pathology , genetics , microbiology and biotechnology
BALB/c and C3H‐ mice were given a single injection of methylcholanthrene (MCA) and were tested at various times thereafter for immunologic reactivity and resistance to syngeneic tumor challenge. MCA treatment did not affect the rejection of H‐2‐incompatible tumor allografts, the rejection of H‐2‐compatible skin allografts, or the induction of delayed hypersensitivity to DNCB as measured by footpad challenge. In contrast, mice treated with MCA exhibited an increased susceptibility to challenge with several syngeneic ultraviolet‐induced and MCA‐induced fibrosarcomas. These studies demonstrate that in the autochthonous host the measurement of host immune status by in vivo cell‐mediated immune responses to exogenous antigens does not necessarily predict the host response to tumor growth.