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Genetic transmission of mammary tumour virus in the DBAf mouse strain
Author(s) -
Verstraeten A. A.,
Van Nie R.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210412
Subject(s) - strain (injury) , biology , virology , virus , transmission (telecommunications) , mammary gland , genetics , cancer , anatomy , breast cancer , electrical engineering , engineering
MTV antigens were demonstrable by radio‐immunoassay in milk samples from individual DBAf mice, and in samples from (♀B́LB/c × ♂DBAf) F 1 mice. Although some samples collected during the first lactation periods of these mice were virus‐negative, all samples of later lactation periods were virus‐positive. From 75 mice of the [♀(♂BALB/c× ♂ BALB/c× DBAf)]Bc I population, milk samples were collected during one or more lactation periods and tested for the presence of viral antigens; the samples of 42 mice were virus‐positive. In the {([BALB/c ×(BALB/c × DBAf)]) × BALB/c}Bc II population two groups were distinguished. In the first group, the progeny of virus‐positive Bc I mothers, 37 out of 62 mice had detectable levels of viral antigen in the milk. None of the 43 samples from mice of the second group, derived from MTV‐negative Bc I females, were virus‐positive. These data suggest that the presence of viral antigens in the milk of DBAf mice is controlled by a single dominant gene; evidence for linkage of this gene and the albino locus was obtained (recombination percentage: 20).