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Unique and common tumor‐specific transplantation antigens of chemically induced mouse sarcomas
Author(s) -
Hellström Karl Erik,
Hellström Ingegerd,
Brown Joseph P.
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210311
Subject(s) - antigen , immunogenicity , transplantation , biology , virology , murine leukemia virus , methylcholanthrene , leukemia , neoplasm , virus , cancer research , immunology , medicine , carcinogen , genetics , surgery
Methylcholanthrene‐induced sarcomas of BALB/c mice express unique tumor specific transplantation antigens (TSTA), and weaker, common TSTA. Antigens of endogenous murine leukemia virus (MuLV) expressed by some of these tumors cannot completely account for these common TSTA. However, MuLV antigens on the immunizing tumor appear to increase the immunogenicity of the common TSTA.