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Screening of human brain tumors for SV40‐related T antigen
Author(s) -
Tabuchi Kazuo,
Kirsch Wolff M.,
Low Margaret,
Gaskin Doris,
van Buskirk John,
Maa Shane
Publication year - 1978
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910210104
Subject(s) - choroid plexus papilloma , ependymoma , choroid plexus , antigen , pathology , human brain , in vivo , biology , in vitro , papilloma , staining , medicine , immunology , central nervous system , endocrinology , biochemistry , microbiology and biotechnology , neuroscience
A series of 39 human brain tumors has been screened for the presence or absence of SV40‐related T antigen by the direct and indirect immuno‐peroxidase methods. Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vitro . The relationship of these tumors to their experimental counterparts inducible by recent human papova‐virus isolates is discussed.