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Production of hybrid cells by fusion of human malignant tumour cells and primary mouse embryo cells
Author(s) -
Watkins J. F.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200410
Subject(s) - embryo , biology , cell fusion , chromosome , microbiology and biotechnology , cell culture , genetics , gene
Hybrid cells with a subtetraploid mouse chromosome complement were produced by fusion of three types of human tumour cells with primary mouse embryo cells. The most frequently present presumptive human chromosome was 21. Numerous chromosome rearrangements were present. Some hybrid cells produced regressing tumours in mice.