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Mechanism of Corynebacterium parvum anti‐tumour activity. II. Protective effect in T‐cell‐deprived mice
Author(s) -
Mazurek Cypka,
Chalvet Huguette,
Stiffel Claude,
Biozzi Guido
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200409
Subject(s) - corynebacterium parvum , thymectomy , bone marrow , mammary carcinoma , cell , ratón , biology , cancer research , immunology , carcinoma , medicine , biochemistry , myasthenia gravis
The natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult C 3 H mice or in mice thymectomized, lethally irradiated and restored with bone‐marrow cells (Tx RB). The protective effect of C. parvum was not modified by adult thymectomy but it was reduced in Tx RB mice. The injection of thymic cells to Tx RB mice or the elimination of T cell precursors in bone‐marrow cells injected in Tx RB mice did not increase the protective effect of C. parvum . These results were compatible with the hypothesis that T cells do not intervene in the mechanism of C. parvum protective effect.