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Photosensitivity of dna‐bound 7,12‐dimethylbenz(a)‐anthracene
Author(s) -
Baird William M.,
Dipple Anthony
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200315
Subject(s) - dmba , 7,12 dimethylbenz[a]anthracene , anthracene , dna , carcinogen , chemistry , photosensitivity , photochemistry , biochemistry , carcinogenesis , materials science , optoelectronics , gene
Structural information about the products formed when 7,12‐dimethylbenz( a )anthracene (DMBA) is bound to DNA in mammalian cell cultures has been sought through studies of the photosensitivities of these products and of various model compounds. Under conditions of light exposure in which the DNA‐DMBA products were highly photosensitive, 8,9,10,11‐tetrahydro‐DMBA and 5,6‐dihydro‐DMBA were stable, whereas 9,10‐dimethyl‐anthracene and DMBA itself were highly photosensitive. This indicates that in the binding reaction with DNA, DMBA retains either the aromatic benz( a )anthracene nucleus or is metabotically activated in the 1,2,3,4‐ring.