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Membrane receptor stripping confirms the association between ebv receptors and complement receptors on the surface of human b lymphoma lines
Author(s) -
Yefenof Eitan,
Klein George
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200305
Subject(s) - receptor , lymphoma , cell surface receptor , biology , complement receptor , immunology , virology , complement system , antibody , biochemistry
Complement (C3) receptors, EBV receptors, Fc receptors, membrane IgM and beta 2 microglobulin (β 2 m) were individually stripped from the surface of human B lymphoma lines. The cells were subsequently tested for their ability to absorb infectious EB virus. Stripping of Fc receptors, IgM and β 2 m did not reduce EBV absorption. Stripping of either EBV receptors or C3 receptors eliminated or drastically reduced EBV‐absorptive capacity. The results confirm the distinctive association between EBV receptors and C3 receptors on human lymphoma cells.