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Ascorbic acid prevents liver tumour production by aminopyrine and nitrite in the rat
Author(s) -
Chan W. C.,
Fong Y. Y.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200215
Subject(s) - ascorbic acid , nitrosation , sodium nitrite , nitrite , in vivo , kidney , sodium ascorbate , chemistry , lung , biochemistry , pharmacology , medicine , biology , food science , microbiology and biotechnology , organic chemistry , nitrate
Massive doses of vitamin C protected rats against liver tumour production by aminopyrine and sodium nitrite, but the protection against lung and kidney tumour production was not complete. The mechanism is in part due to blockage of in vivo nitrosation. Other unknown factors may operate to give the liver complete protection.