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Studies of bone and soft‐tissue tumours induced in rats with radioactive cerium chloride
Author(s) -
Klein B.,
Pals S.,
Masse R.,
Lafuma J.,
Morin M.,
Binart N.,
Jasmin J. R.,
Jasmin C.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200118
Subject(s) - bone tumours , soft tissue , osteosarcoma , pathology , sarcoma , fibrosarcoma , chondrosarcoma , medicine , chemistry
Abstract A colloidal suspension of radioactive cerium chloride was inoculated into the hind legs of Sprague Dawley rats. Bone and soft‐tissue tumours were induced at the site of inoculation in 77% of the animals. All bone tumours were osteogenic osteo‐sarcomas. Soft tissue tumours were mostly malignant and were of various histological types, predominantly fibrosarcomas, haemangiopericytomas, angiosarcomas and rhabdomyosarcomas. A kinetic study showed that the doubling time (DT) of tumours was closely correlated with the anatomical site of tumour development: bone tumours had a DT of 17.4±4.3 days and malignant tumours which developed in soft tissues had a DT ranging from 7.4 to 8.4 days with the exception of two haeman‐giosarcomas which had a long DT of 17±0.6 days. Pulmonary metastases were frequent for osteo‐sarcomas and tumours of vascular origin. This model of induction of bone and soft‐tissue tumours in rats by injection of a colloidal suspension of radioactive cerium chloride offers the possibility of more comprehensive physiopathological and kinetic studies of these tumours and may constitute a good model for their human counterparts.