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Epstein‐Barr herpesvirus infection: Inhibition by immunologically induced mediators with interferon‐like properties
Author(s) -
Lai P. K.,
Alpers P.,
MacKayScollay E. M.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910200106
Subject(s) - interferon , virology , immunology , biology , gammaherpesvirinae , herpesviridae , medicine , virus , viral disease
When sensitized leukocytes were re‐exposed to EBV antigen or to tuberculin‐purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea‐pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited EBV‐induced transformation and EBV superinfection of target cells. Unsensitized leucocytes from sero‐negative adults and from neonates did not produce lymphokines when challenged with the antigens. This indicates that cell‐mediated immunity and its associated soluble mediators may be involved in the control of EBV infection and that the interferon release assay is a useful in vitro correlate for the study of cellular immunity to EBV.