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Immune response of athymic nude mice to papovavirus SV40 tumor‐associated antigens
Author(s) -
Tevethia Satvir S.,
Waneck Gerald,
Tevethia Mary J.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910190516
Subject(s) - antigen , immune system , papovavirus , transplantation , immunology , biology , virus , virology , antibody , nude mouse , in vivo , cancer research , medicine , surgery , microbiology and biotechnology
The requirement of T cell functions in the induction of immune response to SV40‐specific transplantation rejection antigen and intranuclear tumor antigen was studied using athymic nude mice. The results obtained indicated that virus‐immunized athymic nude mice were unable to reject SV40 tumor cell challenge, and sensitized lymphocytes capable of inhibiting tumor growth in vivo could not be demonstrated in the spleens of virus‐immunized mice. Athymic nude mice bearing tumors induced by virus‐free SV40‐transformed BALB/c cells failed to develop antibodies to intranuclear T antigen. Athymic nude mice also failed to respond to viral antigens. Thus it can be concluded that T cell functions are required in the induction of cellular immune response to SV40‐specific transplantation rejection antigen and in humoral immune response to SV40‐specific T antigen and virion antigen.