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Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture
Author(s) -
Strander Hans,
Einhorn Stefan
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910190406
Subject(s) - osteosarcoma , cell culture , interferon , in vitro , growth inhibition , cell growth , tissue culture , cancer research , biology , cell , sarcoma , immunology , pathology , medicine , biochemistry , genetics
Nine osteosarcoma cell lines, originally developed from six osteosarcoma tumours in five patients, and two cell lines of non‐tumour origin (glia and fibro‐blast) were grown in vitro in the presence of human leukocyte interferon (L‐IF). L‐IF exerted a dose‐dependent inhibition of growth in all these lines. The inhibitory activity displayed characteristics typical of interferons. Inhibition of cell growth occurred at a much lower L‐IF concentration for the osteosarcoma than for the non‐tumour‐derived lines. Inhibition of tumour cell growth was observed at concentrations obtained in the serum of osteosarcoma patients treated with interferon.