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Effects of ethylnitrosourea administration during pregnancy on three subsequent generations of bdvi rats
Author(s) -
Tomatis L.,
Ponomarkov V.,
Turusov V.
Publication year - 1977
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910190214
Subject(s) - ethylnitrosourea , carcinogen , pregnancy , kidney , dmba , physiology , biology , gestation , cancer , medicine , lactation , endocrinology , nervous system , incidence (geometry) , genetics , carcinogenesis , gene , mutant , physics , neuroscience , optics
A single dose of 40 mg/kg of N‐nitrosoethylurea (ENU) was administered to BDVI rats on the 16th day of pregnancy. The first generation descendants (F 1 ) were mated on a brother‐to‐sister system to produce a second generation (F 2 ) which was then mated to produce a third generation. A high incidence of nervous tissue tumors and a few kidney tumours were observed in F 1 descendants. A few nervous tissue tumours were observed in F 3 but not in F 2 descendants. These results partially confirm previous observations obtained with 7,12‐dimethylbenz( a )anthracene in mice and nitrosomethylurea in rats and indicate that prenatal exposure to a chemical carcinogen may result in an increased cancer risk which can persist for more than one generation.