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Leukaemias in BN/a and BN/b mice after prolonged treatment with antilymphocyte globulin
Author(s) -
Szkudlarek Jerzy,
Radzikowski Czeslaw,
Czarnomska Alina,
Dux Kazimierz,
Bartoszewicz Wadysaw
Publication year - 1976
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910180615
Subject(s) - ascites , friend virus , antigen , immunosuppression , immunology , virus , lymph , spleen , biology , globulin , b cell , lymphocyte , virology , antibody , medicine , pathology
The influence of prolonged treatment with anti‐lymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non‐thymic lymphomas with involvement of abdominal lymph nodes and spleen resulting in ascites. Three established ascites leukaemia cell lines were examined for the presence of MuLV. In all lines viral C‐type particles, soluble viral gs‐1 antigen and cell surface antigen related to Gross virus were demonstrated. The mechanism of induction of these tumours remains obscure. The hypothetical role of immunosuppression, stimulation of lymphoid cells and activation of leukaemogenic virus is discussed.